Yeztugo may be a good option if you:
- Are HIV negative. Yeztugo is only for people who don’t have HIV.
- Are at risk of getting HIV.
- Weigh at least 77 lbs (35 kg).
- Can come in every 6 months for an HIV test and injection.
Do not use Yeztugo if you
- Are living with HIV, or haven’t had a recent negative HIV test. Yeztugo is for prevention only. If you take it with undiagnosed HIV, the virus can become harder to treat.
- Are allergic to lenacapavir or anything in the medicine.
- Take certain medicines that make Yeztugo work less well, such as some seizure or tuberculosis medicines or St. John’s wort. Your clinician will review all your medication with you.
Tell your clinician if you:
- Have hepatitis B. Yeztugo doesn’t treat it, so you’ll need a plan first.
- Have had flu-like symptoms in the past month, such as fever, fatigue, muscle aches, sore throat, swollen lymph nodes, rash, or night sweats.
- Are pregnant, planning to be, or breastfeeding. See Yeztugo for women, trans people, and pregnancy below
Women, transgender and nonbinary people, and pregnancy
- Women. In a large study of young women in South Africa and Uganda, no one taking Yeztugo got HIV.
- Transgender and nonbinary people. Yeztugo worked well in a study that included transgender and nonbinary people. It doesn’t interfere with gender-affirming hormones, and hormones don’t lower its protection.
- Pregnancy and breastfeeding. The CDC and WHO support using Yeztugo during pregnancy and breastfeeding if you’re at risk for HIV based on available, but limited, data. If you have questions, talk with your clinician.